Table 2.
Effects of a High-Fat Diet (HFD) on Various Serum Biomarkers in Control Rats and Insulin-Like Growth Factor-1/Growth Hormone–Deficient Lewis Dwarf Rats
| Parameter | Control (SD) | Lewis Dwarf (SD) | Control (HFD) | Lewis Dwarf (HFD) | Units |
| Fast triglycerides | 249.3 ± 55.8 | 137.16 ± 37.6 | 88.33 ± 10.6* | 73.4 ± 12.1* | mg/dL |
| Fast cholesterol | 122.5 ± 8.7 | 110.67 ± 11.0 | 96 ± 3.69 | 92 ± 1.97 | mg/dL |
| Total protein cc | 6.3 ± 0.17 | 6.1 ± 0.14 | 5.6 ± 0.06* | 5.66 ± 0.09* | g/dL |
| Albumin | 3.8 ± 0.09 | 3.71 ± 0.08 | 3.45 ± 0.03* | 3.48 ± 0.07* | g/dL |
| ALP | 95 ± 11.24 | 109 ± 12.20 | 116.3 ± 5.07 | 103.8 ± 13.9 | U/L |
| SGOT/AST | 129.6 ± 12.5 | 188.5 ± 26.21 | 182.16 ± 19.0 | 230 ± 51.19 | U/L |
| SGPT/ALT | 55.6 ± 4.7 | 69.67 ± 6.7 | 107.33 ± 17.6 | 96.6 ± 21.23 | U/L |
| Bilirubin | <0.1 | <0.1 | <0.1 | <0.1 | mg/dL |
| BUN | 15.1 ± 0.95 | 17.67 ± 0.77 | 12.83 ± 0.48 | 11.4 ± 0.68† | mg/dL |
| Creatinine | 0.45 ± 0.03 | 0.45 ± 0.03 | 0.43 ± 0.02 | 0.40 ± 0.03 | mg/dL |
| Cl | 105.3 ± 1.1 | 103.3 ± 0.4 | 105.8 ± 1.2 | 107.6 ± 1.2† | mmol/L |
| Na | 142 ± 1 | 140 ± 0.5 | 141.1 ± 1.4 | 143.4 ± 1.4 | mmol/L |
| K | 6.1 ± 0.7 | 6.5 ± 0.3 | 5.9 ± 0.3 | 6.3 ± 0.6 | mmol/L |
| Ca | 9.56 ± 0.2 | 9.15 ± 0.12 | 8.91 ± 0.09* | 8.9 ± 0.221 | mmol/L |
| PO4 | 4.06 ± 0.04 | 4.1 ± 0.03 | 3.95 ± 0.04 | 4.06 ± 0.02 | mmol/L |
| C-reactive protein | 377.8 ± 20.3 | 410.4 ± 32.1 | 429.4 ± 10.8 | 392.8 ± 22.8 | μg/mL |
| sVCAM-1 | 169.4 ± 4.8 | 195 ± 7.6* | 181.4 ± 5.3 | 183.8 ± 6.2 | ng/mL |
| VEGF | 252.0 ± 8.6 | 255.0 ± 34.5 | 284.2 ± 10.5 | 247.5 ± 34.9 | pg/mL |
| von Willebrand factor (vWF) | 83.74 ± 20 | 121.5 ± 21 | 91.24 ± 17.6 | 105.7 ± 14.7 | ng/mL |
| Tissue factor | 8.92 ± 0.64 | 6.58 ± 1.21 | 9.05 ± 1.03 | 4.22 ± 1.01 | ng/mL |
| Haptoglobin | 805.4 ± 80.6 | 603.6 ± 175 | 721 ± 58.4 | 657.8 ± 157.2 | μg/mL |
| ACE | 45.1 ± 2.6 | 51.5 ± 5.4 | 38.7 ± 3.2 | 42.6 ± 6.4 | ng/mL |
| Angiotensinogen | 232.6 ± 8.2 | 238.2 ± 6.4 | 229.4 ± 11.5 | 237.4 ± 5.2 | μg/mL |
Notes: Data are mean ± SEM (n = 5–7 for each data point). VEGF = vascular endothelial growth factor.
*p < .05 versus SD-fed control; †p < .05 versus SD-fed Lewis dwarf.