Table 3.

The Comparison of Pentosidine Formation Rate in Skin Collagen of Ansell's Mole-Rats With Other Animal Species^*

				Correlation With Age
Species	Maximum Life Span (y)†	Level vs Age Regression Line Model (quadratic equation)	n	r	p	Pentosidine Formation Rate (coefficient of x2)
Fischer 344 rat	3.0	y = 0.182x2 + 0.066x + 0.006	26	.93	<.0001	0.1823
DBA mouse	2.5	y = 0.059x2 + 0.068x + 0.020	50	.94	<.0001	0.0593
C57 mouse	3.0	y = 0.036x2 + 0.072x + 0.036	31	.64	.0001	0.0357
Least shrew	3.5	y = 0.081x2 + 0.195x + 0.118	41	.96	<.0001	0.0807
Dog	20	y = 0.044x2 + 0.334x + 0.634	44	.93	<.0001	0.0441
Cow	20(30)†	y = 0.042x2 + 0.235x + 0.326	17	.92	<.0001	0.0424
Pig	27	y = 0.020x2 + 0.083x + 0.087	37	.98	<.0001	0.0196
Ansell’s mole-rat	20‡	y = 0.007x2 + 0.123x + 0.517	36	.74§	<.0001	0.0073
Squirrel monkey	30	y = 0.002x2 + 0.003x + 0.746	42	.40	.008	0.0017
Rhesus monkey	40	y = 0.001x2 + 0.070x + 0.990	41	.75	<.0001	0.0012
Human	120	y = 0.002x2 + 0.088x + 0.927	44	.93	<.0001	0.0020

Notes: Plot of pentosidine level (y, picomoles per milligram collagen) versus age (x, years) was modeled by a quadratic equation for each animal species (26).

^*Pentosidine formation rate was determined by the coefficient of x² (26).

^†Maximum life spans were from Sell and colleagues (26) and updated using the following sources: de Magalhaes and Costa (44); that is, An Age/The Animal Ageing & Longevity Database (http://genomics.senescence.info/species/); F344 rat, DBA, and C57 mouse were from Turturro and colleagues (45); domestic cow is estimated to be either 20 (46) or 30 years (47).

^‡The maximum reported life span for Ansell's mole-rat is ≈20 years (5). However, this is an underestimation due to the original mole-rat had been caught in the wild as an adult of unknown age and survived in the laboratory for more than 19 years.

^§To allow comparisons with the other results, this value was derived from r² in Model 1 (Table 2) without correction for status or sex.