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Isolated endocrine insulin-like growth factor (IGF)-1 deficiency impairs contractile properties of cardiomyocytes, mimicking the aging phenotype. Shown are (A) maximal velocity of shortening (+dL/dt) and (B) maximal velocity of relengthening (−dL/dt) in cardiomyocytes isolated from young (2- to 4-month-old) and old (24- to 26-month-old) C57BL/6 and young LID mouse hearts. *p < .05. Data are mean ± SEM. Data points are replotted from (68).
