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. Author manuscript; available in PMC: 2013 May 4.
Published in final edited form as: Cell Stem Cell. 2012 May 4;10(5):620–634. doi: 10.1016/j.stem.2012.02.013

Figure 7. Implications of aberrations in XCI and genomic imprints on disease modeling.

Figure 7

A. DNA methylation (450K DNA Methylation array) of 214 gametic imprinted CpG sites at imprinted loci for control androgenetic and gynogenetic samples, undifferentiated (labeled with green text) and differentiated (labeled with red text) hPSC samples. Arrows indicate direction of differentiation. B. The heatmap shows DNA methylation (450K DNA Methylation array) on the X chromosome for control male tissue samples, control female tissue samples, undifferentiated samples (labeled with green text) and differentiated samples (labeled with red text) hPSC samples. Arrows indicate direction of differentiation. CpGs are ordered by chromosomal location, with the cytobands indicated to the left of the heatmap. C. Diagram indicating the frequency of loss of XCI at X-linked disease genes among 11 hiPSC clones reprogrammed from the same fibroblast culture. The number of clones showing loss of XCI at each locus is listed to the right of the gene name. Genes with loss of XCI in 1–3 clones are shown in black, in 4–5 clones in orange, and in 6–8 clones in red.