TABLE I.
Association of PSA Levels With 16 SNPs in Men Without a Prostate Cancer Diagnosis
| Allele (frequency) |
No. of subjects by genotype |
Least square mean PSA (ng/ml)c |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Region | Positiona | Normal | Risk | NNb | NRb | RRb | NNb | NRb | RRb | Pd | |
| rs721048 | 2p15 | 63,043,382 | G (0.81) | A (0.19) | 1,126 | 528 | 55 | 1.57 | 1.55 | 1.57 | 0.86 |
| rs2660753 | 3p12 | 87,193,364 | C (0.92) | T (0.08) | 1,430 | 240 | 10 | 1.57 | 1.49 | 2.37 | 0.78 |
| rs9364554 | 6q25 | 160,804,075 | C (0.69) | T (0.31) | 807 | 692 | 170 | 1.62 | 1.51 | 1.63 | 0.50 |
| rs10486567 | 7p15 | 27,749,803 | T (0.24) | C (0.76) | 103 | 604 | 103 | 1.25 | 1.47 | 1.67 | 3.0E–04 |
| rs6465657 | 7q21 | 97,460,978 | T (0.53) | C (0.47) | 489 | 796 | 400 | 1.52 | 1.58 | 1.60 | 0.45 |
| rs16901979 | 8q24 (2) | 128,194,098 | C (0.97) | A (0.03) | 1,591 | 117 | 0 | 1.54 | 1.79 | — | 0.09 |
| rs6983267 | 8q24 (3) | 128,482,487 | T (0.49) | G (0.51) | 419 | 828 | 457 | 1.47 | 1.57 | 1.63 | 0.10 |
| rs1447295 | 8q24(1) | 128,554,220 | C (0.86) | A (0.14) | 1,271 | 392 | 44 | 1.54 | 1.62 | 1.36 | 0.87 |
| rs1571801 | 9q33 | 121,506,927 | G (0.72) | T (0.28) | 870 | 708 | 131 | 1.58 | 1.51 | 1.75 | 0.79 |
| rs10993994 | 10q11 | 51,219,502 | C (0.61) | T (0.39) | 627 | 810 | 264 | 1.44 | 1.58 | 1.79 | 1.0E–03 |
| rs4962416 | 10q26 | 126,686,862 | A (0.77) | G (0.23) | 988 | 594 | 89 | 1.49 | 1.63 | 1.93 | 6.0E–03 |
| rs10896449 | 11q13 | 68,751,243 | A (0.54) | G (0.46) | 477 | 867 | 342 | 1.57 | 1.52 | 1.72 | 0.24 |
| rs4430796 | 17q12 | 33,172,153 | C (0.44) | T (0.56) | 316 | 883 | 509 | 1.5 | 1.53 | 1.75 | 7.9E–05 |
| rs1859962 | 17q24.3 | 66,620,348 | T (0.50) | G (0.50) | 411 | 870 | 426 | 1.53 | 1.53 | 1.65 | 0.23 |
| rs2735839 | 19q13 | 56,056,435 | A (0.12) | G (0.88) | 29 | 345 | 1,308 | 1.19 | 1.49 | 1.60 | 0.05 |
| rs5945619 | Xp11 | 51,074,708 | A (0.62) | G (0.38) | 1,048 | 0 | 641 | 1.51 | — | 1.65 | 0.05 |
a
Build35.
b
NN denotes homozygous for non-risk allele; NR for heterozygous; and RR for homozygous risk allele.
c
PSA levels were log-transformed and adjusted for age and geographic region. The values presented were back-transformed.
d
Test were based on log-transformed PSA levels and assuming an additive model.