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. 2011 Nov 17;2012:262394. doi: 10.1155/2012/262394

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Copyright © 2012 Tomoko Hayashi et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Tolerimod1 treatment reduced local chemokine release but had no effect on systemic proinflammatory cytokine levels. TG-elicited peritonitis was induced in Tolerimod1 (TLM1) or vehicle (veh)-treated mice (n = 8–10 per group). Sera and peritoneal lavage were harvested 3 h after TG injection. Levels of KC (a) and IL-1β (b) in the lavage and KC (c) and IL-6 (d) in sera were measured by ELISA. IL-1β, TNFα, and IL-10 in the sera or lavage, or IL-6 in the lavage, were below detection levels. (e) Vascular permeability was measured by Evans blue assay. Peritoneal lavage was collected 2 h after TG injection. Data shown are mean ± SEM and are pooled from 2 independent experiments that showed similar trends. P values are compared between vehicle (veh)- and Tolerimod1 (TLM1)-treated group by Mann-Whitney test. NS indicates not significant.