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(A) The accumulation of AGEs increased with ribosylation incubation time in both the annulus fibrosis (p<0.001; ANOVA) and the nucleus pulposus (p<0.001; ANOVA). (B) The increases in AGEs also corresponded with the decrease in the tissue water mass in these IVD tissues. Water content in the intervertebral disc tissues decreased significantly with incubation time in both the annulus fibrosis (p<0.001; ANOVA) and the nucleus pulposus (p<0.001; ANOVA).
