Table 8.

Shown are the calculated and experimental absolute standard state solubility free energies $\mathrm{\Delta }{\text{G}}_{\text{solubility}}^{\text{o}}$ for the n-alkylamides from acetamide to octanamide (kcal/mol) based on summing $\mathrm{\Delta }{\text{G}}_{\text{sub}}^{\text{o}}$ and $\mathrm{\Delta }{\text{G}}_{\text{solv}}^{\text{o}}$. The

n-Alkylamide	$\mathrm{\Delta }{\text{G}}_{\text{sub}}^{\text{o}}$	$\mathrm{\Delta }{\text{G}}_{\text{solv}}^{\text{o}}$	$\mathrm{\Delta }{\text{G}}_{\text{solubility}}^{\text{o}}$			Log (S)a
			Calc.	Expt.	Error	Calc.	Expt.	Error
Acetamide	10.9	−10.3	0.6	−0.18	0.8	1.0	1.2	0.3
Propanamide	8.5	−8.3	0.1			0.9
Butanamide	10.5	−10.5	0.0	−0.27	0.3	0.2	0.4	0.2
Pentanamide	11.2	−9.7	1.5	0.14	1.4	−1.1	−0.1	1.0
Hexanamide	12.0	−9.4	2.6	0.80	1.8	−1.9	−0.6	1.3
Heptanamide	13.0	−9.5	3.5			−2.6
Octanamide	14.4	−9.4	5.0			−3.6
Mean					1.1			0.7

^aSolubility (S) in units of mol/L is calculated from $S=exp[(-\mathrm{\Delta }{G}_{\text{solubility}}^{\text{o}}+\mathrm{\Delta }{\text{G}}_{\text{excess}})/{\text{k}}_{\text{B}}T]$ where ΔG_excess was given in Table 5, k_B is the Boltzmann constant and T is temperature (298°K).