Table 2.
Association of inflammation related genes with overall survival in discovery population using expression microarrays
| Gene Expression | No. Death (%)
|
HR (95% CI)* | p Value | |
|---|---|---|---|---|
| No | Yes | |||
| ADORA3:† | 0.00036 | |||
| Low | 55 (77.46) | 14 (66.67) | 1 (referent) | |
| High | 16 (22.54) | 7 (33.33) | 21.34 (3.97–114.61) | |
| CARD9:† | 0.0026 | |||
| Low | 51 (71.83) | 10 (47.62) | 1 (referent) | |
| High | 20 (28.17) | 11 (52.38) | 7.11 (1.98–25.49) | |
| CASP2 + RIPK1 domain containing adaptor with death domain: | 0.0050 | |||
| Low | 34 (47.89) | 14 (66.67) | 1 (referent) | |
| High | 37 (52.11) | 7 (33.33) | 0.14 (0.036–0.56) | |
| NCF2: | 0.0051 | |||
| Low | 41 (57.75) | 7 (33.33) | 1 (referent) | |
| High | 30 (42.25) | 14 (66.67) | 5.87 (1.70–20.26) | |
| Suppressor of cytokine signaling 1: | 0.0075 | |||
| Low | 56 (78.87) | 13 (61.90) | 1 (referent) | |
| High | 15 (21.13) | 8 (38.10) | 4.98 (1.54–16.13) | |
| Epstein-Barr virus induced 3: | 0.017 | |||
| Low | 38 (53.52) | 8 (38.10) | 1 (referent) | |
| High | 33 (46.48) | 13 (61.90) | 4.40 (1.30–14.87) | |
| CIITA: | 0.021 | |||
| Low | 62 (87.32) | 15 (71.43) | 1 (referent) | |
| High | 9 (12.68) | 6 (28.57) | 4.19 (1.24–14.14) | |
*
Adjusted for age at diagnosis, gender, BMI, family history of cancer, race, hypertension, smoking status and stage.
†
Also significant for recurrence.