TABLE 1.
FDR significanti results from weighted GWAS
| Costa Rica RCHH | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Location (Chr: BP in hg18) |
A1 | OR | Original P valueii |
Original rank |
Weighted P valueiii |
Gene (distance from gene) |
Norway P valueiv |
NETT-NAS P value |
Eclipse P value |
Cases (%) |
Controls (%) |
RCHH P value |
| rs1903003 | 4:90105320 | C | 0.75 | 7.18E-08 | 1 | 6.87E-08 | FAM13A0) | 4.3E-04 | 1.4E-03 | 9.1E-03 | 1 (2%) | 0 (0%) | 0.2126 |
| rs7671167 | 4:90103002 | C | 0.76 | 8.59E-08 | 2 | 8.22E-08 | FAM13A(0) | 7.9E-04 | 2.7E-04 | 7.8E-03 | 1 (2%) | 0 (0%) | 0.2126 |
| rs1062980 | 15:76579582 | C | 0.76 | 4.81E-07 | 3 | 9.53E-08 | IREB2(0) | 9.9E-03 | 1.0E-02 | 3.6E-02 | 5 (9%) | 0 (0%) | 0.0164 |
| rs13180 | 15:76576543 | C | 0.76 | 5.01E-07 | 4 | 9.93E-08 | IREB2(0) | 7.9E-03 | 1.6E-02 | 4.3E-02 | 5 (9%) | 0 (0%) | 0.0164 |
| rs8034191 | 15:76593078 | C | 1.32 | 5.37E-07 | 5 | 1.06E-07 | IREB2(+12.22kb) | 1.5E-04 | 8.7E-03 | 8.2E-01 | 5 (9%) | 0 (0%) | 0.0164 |
| rs12914385 | 15:76685778 | T | 1.29 | 1.42E-06 | 9 | 2.81E-07 | CHRNA3(0) | 1.4E-03 | 9.8E-03 | 9.5E-01 | 5 (9%) | 0 (0%) | 0.0164 |
| rs1051730 | 15:76681394 | A | 1.29 | 2.80E-06 | 14 | 5.54E-07 | CHRNA3(0) | 4.3E-04 | 2.1E-02 | 8.4E-01 | 5 (9%) | 0 (0%) | 0.0164 |
| rs17404727 | 15:47791375 | C | 1.28 | 4.71E-06 | 15 | 7.17E-07 | . | 1.9E-02 | 2.2E-02 | 3.4E-02 | 7 (12%) | 0 (0%) | 0.0049 |
| rs996414 | 9:26570067 | G | 0.76 | 1.80E-06 | 11 | 8.76E-07 | . | 6.2E-04 | 8.8E-01 | 2.6E-01 | 2 (3%) | 0 (0%) | 0.1063 |
| rs4480740 | 15:47543134 | A | 1.27 | 6.75E-06 | 17 | 1.03E-06 | FGF7(0) | 4.0E-02 | 2.5E-02 | 2.1E-02 | 7 (12%) | 0 (0%) | 0.0049 |
| rs12591300 | 15:47492033 | A | 1.27 | 8.78E-06 | 21 | 1.34E-06 | FGF7(−10.72kb) | 3.9E-02 | 8.3E-02 | 2.5E-02 | 7 (12%) | 0 (0%) | 0.0049 |
| rs2656069 | 15:76532762 | C | 0.75 | 6.82E-06 | 18 | 1.35E-06 | IREB2(0) | 1.6E-01 | 2.6E-03 | 1.0E-02 | 5 (9%) | 0 (0%) | 0.0164 |
| rs2036534 | 15:76614003 | C | 0.75 | 6.98E-06 | 19 | 1.38E-06 | PSMA4(−5.798kb) | 5.8E-02 | 7.4E-03 | 9.4E-02 | 5 (9%) | 0 (0%) | 0.0164 |
| rs2869967 | 4:90088355 | C | 1.29 | 1.48E-06 | 10 | 1.41E-06 | FAM13A1(0) | 4.7E-04 | 7.6E-03 | 4.4E-03 | 1 (2%) | 0 (0%) | 0.2126 |
i
An FDR corrected P value of 1.43e10−6 was used as the cutoff for genome-wide significance.
ii
Results previously published by Cho, et. al, 1
iii
The weighted P value is the original P value divided by the weight constructed from the RCHH (not shown).
iv
P values for individual cohorts are the original, unweighted P values.