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. 2011 Jul 6;31(27):9945–9957. doi: 10.1523/JNEUROSCI.1802-11.2011

Figure 4.

Figure 4.

LFB-PAS. Luxol fast blue/periodic acid–Schiff staining of the anterior commissure of the corpus callosum of representative animals is shown (A–D). The untreated wt animal (A) has essentially no PAS-positive macrophages within the white matter, the untreated mut (B) mouse shows prominent PAS-positive macrophages within the white matter (arrowheads), and both the AAV-mut (C) and AAV+BMT-mut (D) mice show a reduction in the number of PAS-positive macrophages in this region of the brain. Sections from the lateral white matter of the spinal cord from an untreated wt mouse (E) show no PAS-positive macrophages within the white matter, whereas sections from the same area of an untreated 36-d-old twitcher mouse (F) show numerous PAS-positive macrophages (arrowheads). There appears to be a slight reduction of PAS-positive cells in the spinal cords of both the AAV-mut (G) and AAV+BMT-mut groups (H).