Figure 7.
Tremor. The averaged power spectrum (A) of the untreated mut group (blue line) is shifted toward higher frequencies with a broader bandwidth compared with the untreated wt group (solid black line). In the AAV-mut group (red line), the averaged power spectrum is similar to that of the untreated wild type. In the AAV+BMT-mut group (solid gray line), the power spectrum is shifted toward higher frequencies compared with the AAV-mut group and is similar to the untreated mut group. Compared with the untreated wt group, there is a significant increase in the frequency of peak power (B) and the power between 13 and 20 Hz (C) in the AAV+BMT-mut group, but not the AAV-mut group. The distance traveled by the AAV-mut and AAV+BMT-mut groups (D) is significantly increased compared with the untreated mut group. BMT alone altered the tremor phenotype in the wild-type mouse. The averaged power spectrum (A) of the BMT-WT group (solid green line) is shifted upward and rightward compared with the untreated wt group (solid black line). The frequency of peak power (B) and the power between 13 and 20 Hz (C) were significantly increased in the BMT-WT group compared with the untreated wild-type group. The distance traveled by the BMT-WT group was significantly decreased compared with the untreated wt group (D). The horizontal bars represent the mean, and the error bars represent SEM. ***p < 0.001; **p < 0.01; *p < 0.05.