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. 2011 Jul 6;31(27):9945–9957. doi: 10.1523/JNEUROSCI.1802-11.2011

Figure 9.

Figure 9.

Chemokines and cytokines. There is a significant increase in KC (A) in the brains of the untreated mut animals compared with the untreated wt animals. The chemokine MCP-1 (B) is increased in the untreated mut group and is undetectable in the untreated wt group. In both the AAV-mut and AAV+BMT-mut groups, KC and MCP-1 levels are reduced similar to the untreated wt group. The BMT-mut group does not show a decrease in the above chemokines compared with the untreated mut group. The chemokine MIP-1β (C) is undetectable in the untreated mut group and is present in the AAV-mut and AAV+BMT-mut groups at levels comparable with the untreated wt group. The levels of MIP-1β in the BMT-mut group are similar to that of the untreated mut group. The cytokine TNF-α (D) is significantly decreased in the untreated mut group compared with the untreated wt group. In the AAV-mut and AAV+BMT-mut groups, the levels of TNF-α are similar to that of the untreated wt group. The levels of TNF-α in the BMT-mut group are similar to that of the untreated mut group. The cytokine IL-12(p40) (E) shows a trend similar to KC, with a significant increase in the untreated mut group compared with the untreated wt group. Levels of IL-12(p40) in the AAV-mut and AAV+BMT-mut groups are similar to the untreated wt group. The horizontal bars represent mean, and error bars represent SEM. *p < 0.05; **p < 0.01; ***p < 0.001; ns, not significant.