Table 3. Associations between SNPs belonging to NOS2 and NOS3 and two quantitative phenotypes measured in the exhaled breath condensate (Fe_NO level and NO₂–NO₃ level) in non-asthmatic and asthmatic subjects–Single marker analysis.

								Exhaled phenotypes
								FeNO, ppb			NO2-NO3, µmol/mg
Chromosome	Gene	Genotyping method	Marker	Position (bp)	Major allele*	Minor allele	MAF†	beta	95% CI #	P	beta	95% CI #	P
Non-asthmatic subjects
17	NOS2 ‡	610K	rs4795067	23130802	A	G	0.35	−0.04	−0.10; 0.03	0.26	0.13	0.04; 0.22	0.002
		610K	rs6505510	23203917	A	C	0.40	0.10	0.04; 0.17	0.002	0.08	−0.01; 0.17	0.07
7	NOS3 ‡	Taqman	rs1549758	150326659	C	T	0.35	−0.06	−0.10; −0.02	0.0009	0.003	−0.06; 0.06	0.92
		Taqman	rs2853796	150334848	G	T	0.48	0.06	0.02; 0.09	0.0007	−0.02	−0.08; 0.04	0.46
Asthmatic subjects
7	NOS3 ‡	610K	rs743507	150338421	T	C	0.27	0.08	0.03; 0.14	0.004	0.02	−0.07; 0.11	0.65

In bold P-values surviving the adjustment (P≤0.0024 or P≤0.01 for NOS2 and NOS3 respectively).

^*Major allele was consider as baseline allele

^†MAF: Minor allele frequency

^#CI: confidence interval

^‡Analyses were conducted under an additive genetic model for NOS3 SNPs and under recessive or dominant genetic models for NOS2 SNPs and FeNO and EBC NO₂–NO₃ levels respectively.