Table 4. Associations between SNPs belonging to NOS2 and NOS3 with FeNO and total NO2–NO3 levels in exhaled breath condensate in non-asthmatic subjects – Multivariate analysis.
Non-asthmatic subjects | |||||||
Gene | Marker | Baseline allele or genotype versus Risk allele or genotype | Risk allele/genotype frequency | LD D'/r2 | Estimate | 95%CI‡ | p-value |
FeNO, ppb * (N = 341) | |||||||
NOS2 | |||||||
rs12601458 | CC+CA vs AA | 0.14 | 0.38/0.02 | −0.216 | −0.382; −0.050 | 0.01 | |
rs6505510 | AA+AC vs CC | 0.40 | 0.097 | 0.034; 0.159 | 0.003 | ||
FeNO, ppb * (N = 311) | |||||||
NOS3 | rs2853796 | G vs T | 0.48 | 0.056 | 0.024; 0.088 | 0.0007 | |
EBC NO2-NO3, µmol/mg † (N = 490) | |||||||
NOS2 | rs4795067 | AA vs AG+GG | 0.35 | 0.09/0.002 | 0.137 | 0.051; 0.223 | 0.002 |
rs4796190 | TT vs TC+CC | 0.33 | 0.103 | 0.020; 0.186 | 0.015 |
Adjusted for age, sex, height, smoking, centre and principal components.
Adjusted for age, sex and principal components.
95% confidence interval of regression coefficient.