. 2012 May 9;7(5):e36672. doi: 10.1371/journal.pone.0036672

Table 4. Associations between SNPs belonging to NOS2 and NOS3 with Fe_NO and total NO₂–NO₃ levels in exhaled breath condensate in non-asthmatic subjects – Multivariate analysis.

					Non-asthmatic subjects
Gene	Marker	Baseline allele or genotype versus Risk allele or genotype	Risk allele/genotype frequency	LD D'/r²	Estimate	95%CI^‡	p-value
	FeNO, ppb ^* (N = 341)
NOS2
	rs12601458	CC+CA vs AA	0.14	0.38/0.02	−0.216	−0.382; −0.050	0.01
	rs6505510	AA+AC vs CC	0.40		0.097	0.034; 0.159	0.003
	FeNO, ppb ^* (N = 311)
NOS3	rs2853796	G vs T	0.48		0.056	0.024; 0.088	0.0007
	EBC NO₂-NO₃, µmol/mg ^† (N = 490)
NOS2	rs4795067	AA vs AG+GG	0.35	0.09/0.002	0.137	0.051; 0.223	0.002
	rs4796190	TT vs TC+CC	0.33		0.103	0.020; 0.186	0.015

Adjusted for age, sex, height, smoking, centre and principal components.

^†

Adjusted for age, sex and principal components.

^‡

95% confidence interval of regression coefficient.

Table 4. Associations between SNPs belonging to NOS2 and NOS3 with FeNO and total NO2–NO3 levels in exhaled breath condensate in non-asthmatic subjects – Multivariate analysis.