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(A) Normal human brain tissue and rat brain tissue (D) showing astrocytic endfoot membranes studded with OAPs containing AQP4. (B) Altered morphology of clustered OAPs in human glioblastoma tissue. (C) Primary cell culture membranes of human glioblastoma are devoid of OAPs as well as intracerebral RG-2 tumor (E), and the RG-2 cell line (F). Scale bars 100 nm.
