Figure 5. RhoA-ROCK signaling controls nuclear p120 translocation and BrdU labeling.

(A) The level of active RhoA was promoted 5-fold by p120 siRNA and 7-fold with addition of nocodazole. The level of active RhoA promoted by p120 siRNA or p120 siRNA+nocodazole was inhibited by taxol to the baseline. (B) Nuclear BrdU labeling and p120 staining promoted by p120 siRNA+nocodazole was abolished by Taxol, CT-04 (RhoA inhibitor), or Y27632 (ROCK inhibitor). Scale bar indicates 100 μm.