Table 1A.
Stimulus recognition consensus sequences for various TCS stimuli.
| Stimulus | No. of sequences | Position | Recognition sequence1 |
|---|---|---|---|
| Phosphor | 1 | 29–32 | GYLP |
| Osmotic | 4 | 36–158 | NFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREIyrelgISLYTNEA AEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTE IHQGDFS |
| Stress | 6 | 25–135 | LVYKFTAERAGRQSLDDLMNSSLYLMRSELREIPPHDWGKTLKEmdlnlsfdlrvepls kyhlddismhrlrggeivALDDQYTFIQRIPRSHYVLAVGPVPYLYYLHQMr |
| Iron | 6 | 35–64 | HESTEQIQLFEQALRDNRNNDRHIMREIRE |
| Copper | 3 | 37–86 | HSVKVHFAEQDINDLKEISATLERVLNHPDETQARRLMTLEDIVSGYSNVLISLADSH GKTVYHSPGAPDIREFARDAIPDKDARGGEVFLLSGPTMMMPGHGHGHMEHSNWRMISL PVGPLVDGKPIYTLYIALSIDFHLHYINDLMNK |
| Citrate | 4 | 43–182 | asfedyltlhvrdmamnqakiiasndsvisavktrdykrlatianklQRDTDFDYVVIG DRHSIRLYHPNPEKIGYPMQFTKPGALEKGESYFITGKGSMGMAMRAKTPIFDDDGKV IGVVSIGYLVSKIDSWRAEFLLP |
| Fumarate | 4 | 42–181 | SQISDMTRDGLANKALAVARTLADSPEIRQGLQKKPQESGIQAIAEAVRKRNDLLFIVV TDMHSLRYSHPEAQRIGQPFKGDDILKALNGEENVAINRGFLAQALRVFTPIYDENHIS KAQIGVVAIGLELSRVtqqindsrw |
| Nitrate/Nitrite | 8 | 38–151 | sslrDAHAINKAGSLRMQSYRLGYDLPSGEPDKNAHRQMFQQAlhspvltnlnvwyv peavkTRYAHRNANWDGMNNRLQGGDDPWYNENIPNYMNQQDRFTLALDHY Qerkqffec |
Notes:
1
Only the consensus recognition sequences are listed according to Uniprot. Well annotated sensors and organisms were compared as listed in Supplementary material. The sensor protein recognition site composition depends on the signal and is independent of the organism. Exact sequences and positions are aligned in Supplementary material. Accurate numbering according to E. coli proteins can be transferred to other organisms. Conserved amino-acids are labeled in bold print. Less conserved amino-acids are labeled in lowercase.