Table 4.
Recognition of divergent TCS and missing TCS partners.
| Family | Identification | Stimulus | Sensor2 | Regulator2 | Strain | Function |
|---|---|---|---|---|---|---|
| (A)L. pneumophila str. Philadelphia1 | ||||||
| OmpR | Iterative sequence searches with cut off e-30 using OmpR sequences from Enterobacter cloacae | Mg starvation | QseC GI:52841522 Known/annotated by PMID 15448271 |
GI:52841523 which is potential similar to QseB | Philadelphia 1 | Regulated protein FliC; GI: 52841570; Flagella regulation; |
| NarL | Iterative sequence searches with cut off e-30 using NP_288375 E. coli O157:H7 str. EDL933 | Carbon | BarA GI: 52842130 Known/annotated by PMID 15448271 |
GI:52842852 which is potential similar to UvrY | Philadelphia 1 | Regulated protein CsrA; GI:52841018 Carbon storage regulator |
| NarL | Iterative sequence searches with cut off e-30 in E. coli ETEC H10407 | Pheromone | GI:52840952 which is potential similar to EvgA | Philadelphia 1 | Regulated protein EmrY; GI:52841684; antibiotic resistance | |
| Family | Identification | Stimulus | Sensor* | Regulator* | Strain | Function |
| (B)Listeria monocytogenes3 | ||||||
| NarL | Iterative sequence searches with cut off e-30 in E. coli ETEC H10407 | Q4EKW8_LISMO which is potential similar to EvgS | GI: 16804553 which is potential similar to EvgA | EGD-e | Antibiotic resistance | |
| OmpR | Iterative sequence searches with cut off e-30 in B. subtilis; the sequences of these proteins where used to search in the Listeria genome | Stress | GI: 16804620 GI: 16803101 which is potential similar to CSSS_BACSU |
GI: 16804621 which is potential similar to CSSR_BACSU | EGD-e | Regulated protein HtrA; serine protease |
| OmpR | PSI-Blast search in B. subtilis with cut off e-60; the sequences of these sensors where used to search in the Listeria genome | Mg starvation | GI: 16803061 which is potential similar to ZP_03239257 | PhoP GI: 16804539 Known/annotated by PMID 11679669 |
EGD-e | Virulence, antimicrobial peptide resistance |
Notes:
New annotated features (interactions or part of TCS) apparent from sequence searches with various available TCS sequences and domains in the genome sequence (Genbank acc. No.: AE017354, Chien M, et al, 2004). Regulated proteins are given as well as homologous standard TCS. Predicted changes (mainly by their operon context) in their function for L. pneumophila are indicated on the right. The right-most column summarizes which aspect of the TCS is reported here new.
Listed are well characterized homologs from other organisms which have the same function within the same family.
Table contains additional features (interactions or parts of TCS) extending what is already known in KEGG or annotated in Genbank (Acc. No.: AE017262) or Listilist (http://genolist.pasteur.fr/ListiList/). On the left the TCS family is given. Starting from B. subtilis TCS sequences we searched for missing sensor and regulator proteins. The right-most column summarizes which aspect of the TCS is reported here new.