. 2012 May 9;7(5):e36384. doi: 10.1371/journal.pone.0036384

Table 1. Known mediators and inhibitors of insulin signal transduction identified in the HTG Screen.

	Symbol	Gene_ID	G6PC mRNA (Fold vs. siControl)	PDK4 mRNA (Fold vs. siControl)
Insulin signaling components	INSR	3643	1.61^*	1.88^*
	IRS2	8660	2.08^*	1.36^*
	AKT2	208	2.03^*	0.88
	PDK1	5170	2.09^*	1.44^*
	p110-alpha	5290	2.09^*	1.72^*
	p85-beta	5296	2.23^*	1.3^*
Negative regulators of insulin signaling	PTEN	5728	0.36^*	0.71^*
	SOCS1	8651	0.67^*	0.7^*
	SOCS3	9021	0.76^*	0.52^*
	mTOR	2475	0.51^*	0.82^*
	JNK1	5599	0.55^*	0.76^*
	IKKbeta	3551	0.61^*	1.08
	PKC-zeta	5590	0.6^*	0.69^*

Gene expressios are significantly increased or decreased compared to siControl treated samples with p<0.05.