Table 3.
Associations of Parasite Serotype With Prematurity, Disease Severity, and Other Manifestations
| Association | II | NE-II | P Value |
|---|---|---|---|
| A. Associations with prematurity (gestational age <38 weeks) | |||
| All | 20/66 (30)a | 54/114 (47) | .03 |
| Rx | 18/52 (35) | 43/92 (47) | .16 |
| No Rx | 2/14 (14) | 11/22 (50) | .04 |
| B. Associations with disease severity at birth and other manifestations for those who were treated during the first year of life | |||
| Severe, S/MN8 | 33/52 (63)b | 77/93 (83) | <.01 |
| Eye severity score ≥2 at birth | 18/46 (39) | 59/88 (67) | <.01 |
| Systemic | |||
| Splenomegaly | 9/51 (18) | 37/91 (41) | <.01 |
| Hepatomegaly | 14/51 (27) | 42/91 (46) | .03 |
| Thrombocytopenia | 18/50 (36) | 39/89 (44) | .37 |
| Anemia | 7/52 (13) | 18/87 (21) | .28 |
| Skin rash | 8/51 (16) | 29/91 (32) | .04 |
| Jaundice | 28/48 (58) | 59/86 (69) | .23 |
| R/O sepsis | 16/52 (31) | 38/93 (41) | .23 |
| Neurologic/ophthalmologic | |||
| Hydrocephalus | 19/52 (37) | 35/93 (38) | .90 |
| Microcephalus | 5/52 (10) | 13/93 (14) | .60 |
| CNS calcifications | 32/52 (62) | 69/93 (74) | .11 |
| Seizures | 8/52 (15) | 12/93 (13) | .68 |
| Chorioretinal scars | 32/52 (62) | 72/93 (77) | .04 |
| Microphthalmia | 10/52 (19) | 13/92 (14) | .42 |
P values reported are from χ2 tests or Fisher exact tests.
Abbreviations: CNS, central nervous system; R/O, rule out sepsis; Rx, persons in the NCCCTS cohort who were diagnosed in the perinatal period and treated during the first year of life [6–18]; No Rx, persons in the NCCCTS cohort who missed being treated in the first year of life and were referred to the NCCCTS after that time [16, 19, 20]; All, persons in the Rx plus No Rx cohorts; S, severe; S/MN, severe/moderate neurologic disease [8]; II and NE-II serotypes are defined in the Methods section and the Figure 1 legend.
Numerators represent no. of persons born at <38 weeks’ gestation with this parasite serotype in the NCCCTS cohort; denominators represent total no. of persons with this parasite serotype in the NCCCTS cohort. Numbers within parentheses represent the percentage of persons with this parasite serotype in the NCCCTS cohort who were born at <38 weeks’ gestation.
Numerators represent no. of persons in the NCCCTS cohort who were treated during the first year of life who had this manifestation at birth and this parasite serotype; denominators represent total no. of persons in the NCCCTS cohort who were treated during the first year of life with this parasite serotype. Numbers within parentheses represent the percentage of persons in the NCCCTS cohort who were treated during the first year of life who had this manifestation and this parasite serotype.