Table 5.
Associations of Parasite Serotype With Outcomes Later in Life Compared to Literature Data
| II | NE-II | Literature [27] | P Value | |||
|---|---|---|---|---|---|---|
| Rx - Severea | Rx - Severe | No Rxb | II vs NE-II | II vs Literature | NE-II vs Literature | |
| Vision <20/30 | 14/17 (82) | 45/49 (92) | 60/101 (59) | .36 | .10 | <.01 |
| New eye lesions | 8/16 (50) | 27/44 (61) | 90/101 (89) | .56 | <.01 | <.01 |
| New eye lesions–central only | 3/16 (19) | 13/44 (30) | NAc | .52 | Not estimabled | Not estimabled |
| Motor/tone abnormality | 5/17 (29) | 9/49 (18) | 70/101 (69) | .49 | <.01 | <.01 |
| IQ <70 | 6/20 (30) | 17/57 (30) | 86/101 (85) | 1.00 | <.01 | <.01 |
| Decrease in IQ ≥15 | 4/17 (24) | 12/49 (24) | NAc | 1.00 | Not estimabled | Not estimabled |
| Hearing loss >30 db | 0/17 (0) | 0/49 (0) | 14/101 (14) | Not estimable | .22 | <.01 |
Rx indicates persons in the National Collaborative Chicago-based Congenital Toxoplasmosis Study (NCCCTS) cohort who were diagnosed in the perinatal period and treated during the first year of life [6–18]; No Rx, persons in the NCCCTS cohort who missed being treated in the first year of life and were referred to the NCCCTS after that time; All, persons in the Rx plus No Rx cohorts. The II and NE-II serotypes are defined in the Methods section and the Figure 1 legend. P values were computed using Fisher exact test.
Numerators represent no. of persons with this parasite serotype who had all of the following: (1) severe disease at birth [8]; (2) treatment (Rx) during the first year of life in the NCCCTS cohort; and (3) this endpoint later in life; denominators represent no. of persons in the NCCCTS cohort who have this parasite serotype with (1) severe disease at birth and (2) treatment during the first year of life. Nos. within parentheses represent percentage of persons with this parasite serotype, severe disease at birth, and treatment during the first year of life in the NCCCTS cohort who had this endpoint later in life.
Numerators represent no. of persons with endpoint later in life in the Eichenwald study [27]; denominators represent total no. of persons in the Eichenwald study. Nos. within parentheses represent percentage of persons in the Eichenwald study with endpoint later in life.
Data not available.
Not estimable due to 0 cells or data not available.