Table 4.
Observation chamber | Home cages | ||||||
---|---|---|---|---|---|---|---|
Food (g) | Water (ml) | Food (% baseline) | Water (% baseline) | ||||
Study 1 | n | 24 h | 48 h | 24 h | 48 h | ||
Exp. 1 | |||||||
Control | 8 | 7.5 (± 2.8) | 17.8 (± 4.3) | 87.2 (± 9.9) | 105.5 (± 8.8) | 94.6 (± 6.1) | 89.0 (± 2.8) |
2% Isoflurane (2 h) | 8 | 5.2 (± 2.5) | 9.0 (± 1.7 | 102.9 (± 9.9) | 107.4 (± 11.0) | 100.7 (± 7.4) | 106.7 (± 8.0) |
2% Isoflurane (6 h) | 8 | 6.8 (± 2.8) | 13.0 (± 5.1) | 84.4 (± 10.2) | 74.4 (± 6.3 | 94.5 (± 5.6) | 84.6 (± 5.3 |
Exp. 2 | |||||||
Saline | 6 | 3.6 (± 1.6) | 12.1 (± 2.1) | 106.2 (± 10.8) | 93.9 (± 11.2) | 102.5 (± 4.4) | 116.0 (± 11.0) |
0.1 mg/kg Morphine | 6 | 0.5 (± 0.3) | 14.1 (± 3.4) | 106.3 (± 12.1) | 93.3 (± 13.5) | 97.8 (± 9.8 | 91.4 (± 9.5 |
0.3 mg/kg Morphine | 6 | 5.1 (± 1.3) | 5.8 (± 1.5) | 107.6 (± 7.6) | 111.5 (± 12.0) | 94.5 (± 6.5) | 86.2 (± 7.6 |
0.9 mg/kg Morphine | 5 | 0.5 (± 0.1) | 4.1 (± 1.2)* | 118.6 (± 10.0) | 97.9 (± 4.2) | 102.4 (± 10.7) | 80.3 (± 15.6) |
Exp. 3 | |||||||
Control/Saline | 5 | 8.8 (± 2.3) | 17.6 (± 7.0) | 93.5 (± 7.5) | 138.4 (± 25.1) | 78.1 (± 6.3) | 113.8 (± 10.3) |
Control/0.1 mg/kg Morphine | 6 | 7.1 (± 3.5) | 17.9 (± 3.3) | 101.1 (± 7.8) | 82.1 (± 5.5)* | 126.1 (± 17.8)* | 111.8 (± 12.3) |
2% Iso (6 h)/Saline | 6 | 8.0 (± 3.0) | 14.9 (± 5.4) | 91.8 (± 2.9) | 92.1 (± 1.9)* | 96.3 (± 9.5) | 91.1 (± 5.0) |
2% Iso(6 h)/0.1 mg/kg Morphine | 6 | 10.0 (± 2.5) | 16.3 (± 6.3 | 110.1 (± 16.2) | 102.2 (± 9.7)* | 133.0 (± 9.5)* | 97.2 (± 7.8) |
Exp. 4 | |||||||
10 mg/kg Cisplatin | 6 | 2.9 (± 2.2) | 11.9 (± 4.7) | ||||
Study 2 | |||||||
Exp. 5 | |||||||
2.5–4% Iso(6 h)/Saline | 6 | 1.6 (± 0.3) | 2.1 (± 0.2) | 185.2 (± 39.9) | 75.3 (± 7.6) | 93.1 (± 17.1) | 98.5 (± 18.4) |
2.5–4% Iso(6 h)/0.1 mg/kg Morphine | 6 | 3.2 (± 2.6) | 1.7 (± 0.4) | 157.5 (± 33.8) | 90.8 (± 8.9) | 81.4 (± 8.4) | 98.4 (± 5.5) |
p < 0.5, planned comparison, LSD-test vs. saline/control. Values are the mean ± SEM.