Table 1.
Laboratory evaluations
| Tests | Case 1 | Case 2 | Case 3 |
|---|---|---|---|
| Cerebrospinal Fluid | 30 thousand | 15 thousand/ml | |
| Bacterial culture | No growth | No growth | No growth |
| Fungal culture | No fungus | No fungus | No fungus |
| Beta-2-Glycoprotein 1 | ND | WNL | ND |
| Total protein | ND | Mildly elevated | Mildly elevated |
| Glucose | ND | WNL | WNL |
| Electrophoresis | ND | WNL | ND |
| Mercury | ND | WNL | ND |
| Neuronal cell antibody | ND | WNL | ND |
| Infection | |||
| Anti-streptolysin O (ASO) | ND | WNL | ND |
| Lyme disease | Negative | ND | Negative |
| Ebstein –Barr virus | Negative | Negative | Positive |
| RPR | ND | Negative | Negative |
| Anti-Hepatitis B Surface antigen | Negative | Negative | Negative |
| Herpes simplex | ND | Negative | Negative |
| Cryptococcal antigen | ND | Negative | Negative |
| West-Nile | ND | Negative | ND |
| Varicella-Zoster | ND | Negative | Negative |
| Arbovirus | Negative | Negative | ND |
| HIV | Negative | Negative | Negative |
| Rubeola | ND | Negative | ND |
| Anticardiolipine antibody | ND | Negative | ND |
| Diluted Russels Viper Venom test | ND | Negative | ND |
| Blood culture | No growth | No growth | No growth |
| Autoimmune panel | |||
| Sjogren antibody (SSA) | Negative | Negative | ND |
| Sjogren antibody (SSB) | Negative | Negative | ND |
| Antithyroid peroxidase antibody | Negative | Negative | Negative |
| Antithyroglobulin antibody | Negative | Negative | Negative |
| Anti DNA antibody | Negative | Negative | ND |
| Rheumatoid factor | Negative | Negative | ND |
| Anti-nuclear antibody | Negative | Positive | Negative |
| C-Anca | Negative | Negative | ND |
| Anti-Smith | Negative | Negative | |
| Anti-RNP Ribonuclear protein | Negative | Negative | |
| Tumor markers | |||
| CA-125 | WNL | WNL | ND |
| CA 19-9 | WNL | WNL | ND |
| Serum AFP | WNL | WNL | ND |
| LDH | WNL | WNL | ND |
| Quantitative serum beta-hCG | <5 IU/ml | <5 IU/ml | ND |
| Serum Anti-NMDA receptor antibodies | Positive | Positive | Positive |
| Cerebrospinal fluid Anti-NMDA abs | Positive | Positive | positive |
| Miscellaneus tests | |||
| Serum methylmalonic acid | ND | WNL | ND |
| Lead (blood) | ND | WNL | ND |
| Urine porphyrins | ND | WNL | ND |
Abbreviations: NMDA= Anti-N-methyl-D-aspartate, ND=Not done, WNL=within normal limit, CSF=cerebrospinal fluid, AFP=Alpha-fetoprotein, LDH=Lactate dehydrogenase