Table 1.

Important features of MOG.

Size	218 amino acids/27 kDa
Abundance and occurrence	Restricted to CNS, on the outermost surface of myelin sheaths and on oligodendrocytes
	0.05% of myelin proteins
Membrane topology	Single span transmembrane protein:
	– extracellular domain (amino acids 1–117)
	– one transmembrane domain
	– one C-terminal integral membrane domain [Della Gaspera et al. 1998]
Function	Unknown.
	No phenotype in knockout mouse [Delarasse et al. 2003]. Probably adhesion of myelin fibers [Clements et al. 2003] or regulator of classical complement pathway [Johns and Bernard, 1997]. Potential host cell receptor of the rubella virus [Cong et al. 2011].
Structure	IgV-like fold, single glycosylation site (Asn-31), one disulphide bond (Cys24–Cys98) [Breithaupt et al. 2003; Clements et al. 2003].
Sequence conservation	More than 90% among mammals [Pham-Dinh et al. 1993].
Possible pathogenic relevance	Target of encephalitogenic T cells.
	Target of demyelinating Abs in many species including primates.

MOG, myelin oligodendrocyte glycoprotein; CNS, central nervous system; IgV, immunoglobulin V; Abs, antibodies.