Table 4.
Action of different respiratory chain effectors on viability of PC12 cell assessed by LDH release after different time of incubation with different concentration of Cd2+.
| Treatment (1 μM) | Control cells (3, 5, 24 h) | 500 μM Cd2+ (3 h) | 100 μM Cd2+ (5 h) | 100 μM Cd2+ (24 h) |
|---|---|---|---|---|
| Control | 100 | 55 ± 3* | 74 ± 4* | 61 ± 5* |
| FCCP | 96 ± 2 | 62 ± 10 | 89 ± 4** | 75 ± 10 |
| Rotenone | 94 ± 1 | 59 ± 10 | 84 ± 8 | 73 ± 7 |
| Myxothiazol | 95 ± 1 | 52 ± 16 | 85 ± 7 | 71 ± 5 |
| Antimycin A | 96 ± 2 | 48 ± 14 | 82 ± 7 | 72 ± 6 |
| Stigmatellin | 99 ± 2 | 78 ± 5** | 90 ± 5** | 76 ± 1** |
The cell viability is expressed in % to untreated control. Mean ± SE; n = 3–11 independent experiments; *P < 0.05 compared to untreated control; **P < 0.05 compared to Cd(II)-treated control.