Figure 11.

Stepwise gain of functional domains during Foxp3 evolution. The topology and divergence timeline on the phylogenetic tree are adapted from previous studies (Woodburne et al., 2003; Brawand et al., 2008). The presence of a domain in the Foxp3 orthologs is denoted by a plus sign. Within the FKH the presence of Foxp3-specific signature residues is distinguished. The incremental gain of functional domains and signature residues is schematically represented. *The protein data available for lizard (Anolis carolinensis) is restricted to part of the FKH.