Table 2.
Effect of CDAA diet on serum ALT, serum AST, and liver triglyceride levels in the gal3+/+ and gal3−/− mice.
| CDAA diet consumption | |||||
|---|---|---|---|---|---|
| 0 wk | 2 wk | 4 wk | 8 wk | ||
| Serum ALT (IU/L) | Gal-3+/+ | 26.9 ± 4.3 | 48.2 ± 9.8 | 89.9 ± 33.3 | 64.2 ± 17.5 |
| Gal-3−/− | 19.7 ± 1.0 | 109.6 ± 18.3* | 151.2 ± 45.6 | 260.9 ± 101.6 | |
| Serum AST (IU/L) | Gal-3+/+ | 78.6 ± 7.6 | 80.7 ± 10.7 | 117.6 ± 27.3 | 75.7 ± 9.5 |
| Gal-3−/− | 78.5 ± 11.5 | 114.9 ± 15.1 | 153.7 ± 26.6 | 192.1 ± 39.9* | |
| Liver triglyceride (mg/g) | Gal-3+/+ | 13.3 ± 0.5 | 51.7 ± 3.4 | 64.9 ± 5.6 | 75.1 ± 1.7 |
| Gal-3−/− | 15.7 ± 1.0 | 58.1 ± 4.1 | 66.0 ± 4.0 | 88.1 ± 10.7 | |
Results are expressed as mean ± SEM of the values from 4–6 mice in each group. *P < 0.05 in comparison with gal3+/+ mice. CDAA: choline-deficient l-amino-acid-defined diet; ALT: alanine aminotransferase; AST: aspartate aminotransferase.