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. 2011 Nov 4;3(1):31–39. doi: 10.1021/cn200082q

Figure 5.

Figure 5

Morphological comparison of differentiating cells in 3D and 2D environments. Differentiating MLPCs exhibit different morphologies in 3D and 2D environments over time. Cells displayed the formation of extensive processes at day 15 in both 2D and 3D environments. However, process development and branching were visible at day 30 in only the 3D environment. Differentiating cells lost their multipolar morphology and became bipolar or spindle-shaped with decreased viability by day 30 in the 2D environment.