Table 3. Grade 3 or worse toxicity related to irinotecan dose escalation in patients proceeding to the second cycle (n=38).

	Dose escalation
Grade 3 or worse	Yes ( n =10)	No ( n =28)
Anaemia	0	5 (17.8%)
Leukopenia	3 (30%)	9 (32.1%)
Neutropenia	5 (50%)	15 (53.5%)
Thrombocytopenia	0	1 (3.5%)
Bleeding	0	0
Febrile neutropenia	0	1 (3.5%)
Fatigue	0	10
Anorexia	0	4 (14.2%)
Nausea	0	5 (17.8%)
Vomiting	2 (20%)	2 (7.1%)
Stomatitis	0	0
Constipation	0	0
Diarrhoea	1 (10%)	2 (7.1%)
Abdominal pain	0	0
Transaminitis (ALT)	0	2 (7.1%)
Transaminitis (AST)	0	1 (3.5%)
Hyperbilirubinemia	0	1 (3.5%)
Cholinergic symptoms	0	0

Abbreviations: ALT=alanine transaminase; AST=aspartate transaminase.