Table 1. GPER protein expression in prospectively collected tumours related to clinico-pathologic factors in 474 patients with endometrial carcinoma.
|
GPERa
|
|||
|---|---|---|---|
| Variable | High, n (%) | Low, n (%) | P-value |
| Age (years) | 0.05 | ||
| <66 | 187 (74) | 65 (26) | |
| ⩾66 | 146 (66) | 76 (34) | |
| FIGO-09 stage | <0.001 | ||
| I–II | 295 (74) | 103 (26) | |
| III–IV | 38 (50) | 38 (50) | |
| Histologic type | <0.001 | ||
| Endometrioid | 302 (77) | 89 (23) | |
| Non-endometrioid | 31 (37) | 52 (63) | |
| Histologic grade | <0.001 | ||
| Grade 1/2 | 265 (81) | 62 (19) | |
| Grade 3 | 68 (46) | 79 (54) | |
| Metastatic nodes | <0.001 | ||
| Negative | 250 (73) | 95 (27) | |
| Positive | 21 (48) | 23 (52) | |
| Ploidy | <0.001 | ||
| Diploid | 191 (74) | 66 (26) | |
| Aneuploid | 31 (48) | 33 (51) | |
| ERα | <0.001 | ||
| Positive | 292 (80) | 71 (20) | |
| Negative | 41 (37) | 70 (63) | |
Abbreviations: ERα=oestrogen receptor α; GPER=G protein-coupled oestrogen receptor.
a
Low=index 0–3 (lowest quartile), high=index 4–9.