Figure 1.

Effects of ticlopidine and aspirin on gastric ulcer healing (A) and angiogenesis in the granulation tissue (B) 10 days after ulcer induction. Three days after ulcer induction, the mean ulcer size was 78 ± 8 mm². The rats were given vehicle, ticlopidine (100 or 300 mg/kg), or aspirin (30 mg/kg) orally each day from day 3 to day 9 postulcer induction. Ulcer healing is expressed as a percent reduction in ulcer size from that on day 3. *, P < 0.05; **, P < 0.01 vs. the corresponding vehicle-treated group (the statistical analysis was performed by using the raw ulcer area data).