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Platelet aggregation induced by thrombin (A), arachidonic acid (B), and ADP (C). Rats were given vehicle, ticlopidine (300 mg/kg), or aspirin (30 mg/kg) orally each day for 7 days. Three hours after the final dose, platelet-rich plasma was prepared and platelet aggregation in response to the three agonists was assessed. *, P < 0.05; **, P < 0.01; ***, P < 0.001 vs. the corresponding control group.
