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Effects of antiendostatin, anti-VEGF, and control antiserum (IgG) on HUVEC proliferation (A) and apoptosis (B; DAPI staining) after exposure to 5% rat serum. Serum from ticlopidine-treated rats reduced proliferation and increased apoptosis (***, P < 0.001). Antiendostatin abolished the effects of the serum from ticlopidine-treated rats (#, P < 0.05 vs. the “ticlopidine alone” and ticlopidine + IgG groups).
