eTable 2. Characterstics of the study sample for the total cohort and by prevalence of atrial fibrillation (standardized for age according to the 1976 European standard population^*1).

Variable	Total population, n = 5000	Participants without atrial ‧fibrillation, n = 4801	Participants with atrial fibrillation, n = 161
Age, years	51.9±10.6	51.6±10.5	62.2±9.5
Women, %	50	50.4	30.1
Smokers, %	21.4	21.6	12.7
Body mass index, kg/m2	26.3 (23.6 to 29.6)	26.2 (23.6 to 29.5)	28.2 (25.5 to 32.2)
Systolic blood pressure, mmHg	130.6±16.9	130.5±16.9	133.0±17.6
Diastolic blood pressure, mmHg	83.1±9.4	83.1±9.3	82.8±10.9
Heart rate, bpm	69.0±10.7	69.0±10.6	69.3±12.4
Total cholesterol, mg/dL	222±41	222±41	212±43
Total/HDL cholesterol	4.01 (3.28 to 4.92)	4.00 (3.28 to 4.91)	4.54 (3.64 to 5.21)
Diabetes, %	5.9	5.7	11.7
Hypertension, %	45	44.4	70
Cardiac failure, %	17.4	16.8	43.1
Myocardial infarction, %	2.1	1.9	12.2
Stroke, %	1.4	1.2	9.2
PQ interval, ms	158±23	158±23	169±25*2
Biomarker
Creatinine, mg/dL	0.87 (0.78 to 0.97)	0.87 (0.78 to 0.97)	0.94 (0.82 to 1.05)
C-reactive protein, mg/L	1.60 (0.50 to 3.10)	1.60 (0.50 to 3.10)	2.30 (1.30 to 4.68)
N-terminal pro-B-type natriuretic peptide, pg/mL	52.6 (23.1 to 104.9)	51.5 (22.9 to 102.0)	234.5 (60.9 to 884.4)

The data shown are mean±standard deviation for continuous variables and percentage for categorical variables.

^*1The data in this table were standardized for age according to the 1976 European standard population (WHO), in order to allow comparability with other studies.

^*2The PQ interval is shown for persons with sinus rhythm in the study ECG (n = 96 participants with a history of atrial fibrillation)