Skip to main content
. Author manuscript; available in PMC: 2012 Sep 29.
Published in final edited form as: Nature. 2012 Mar 28;483(7391):570–575. doi: 10.1038/nature11005

Figure 2. Biomarkers of drug sensitivity and resistance.

Figure 2

a, Gene-specific volcano plots of drug sensitivity associated with BRAF mutations in cancer cell lines (n = 54). b-k, Scatter plots of cell line IC50 (uM) values from selected drug-gene associations. IC50 values are on a log scale comparing mutated or non-mutated (WT) cell lines. Each circle represents the IC50 of one cell line and the red bar is the geometric mean. The drug name is indicated above each plot and therapeutic drug target(s) are bracketed.