Figure 3. Multi-feature genomic signatures of drug response.

a, The top drug-feature associations identified by the EN are plotted for their frequency and effect size. Associations are colored black for expression features, red for mutations, blue for copy number, and green for tissue. b-c. Heatmaps of highly significant EN features associated with response to b, dasatinib (inhibitor of SRC,ABL) and c, 17-AAG (HSP90 inhibitor) for the 14 most sensitive (purple) and resistant (yellow) cell lines. For each cell line mutation features are at the top of the heatmap shown in black (present) or gray (absent), followed by expression features (blue corresponds to lower expression, red to higher expression). To the left of each feature is a bar indicating the absolute value of the effect size. Bars in purple are negative effects, indicating features associated with sensitivity, and bars in yellow are positive effects, indicating features associated with resistance. The natural log IC₅₀ values are represented at the bottom. For clarity, only the top 4 features associated with sensitivity and resistance to 17-AAG are shown.