Table 2.
| Time off Dox | Pathology
|
Total | ||||
|---|---|---|---|---|---|---|
| None | + | ++ | +++ | |||
| Males | 3 weeks | 3 | 3 | 0 | 0 | 6 |
| 6 weeks | 4 | 1 | 1 | 0 | 6 | |
| 9 weeks | 0 | 2 | 1 | 2 | 5 | |
| 11 weeks | 0 | 2 | 3 | 1 | 6 | |
| 14 weeks | 1 | 2 | 1 | 2 | 6 | |
| Females | 3 weeks | 4 | 2 | 0 | 0 | 6 |
| 6 weeks | 1 | 4 | 0 | 0 | 5 | |
| 9 weeks | 0 | 2 | 1 | 1 | 4 | |
| 12 weeks | 1 | 4 | 0 | 1 | 6 | |
| 15 weeks | 1 | 3 | 0 | 2 | 6 | |
| 18 weeks | 0 | 1 | 1 | 3 | 5 | |
| 21 weeks | 0 | 0 | 1 | 4 | 5 | |
| 24 weeks | 0 | 2 | 1 | 3 | 6 | |
Numbers indicate the number of mice in each cohort exhibiting a particular score. None indicates no differences observed in Iba1, GFAP, or NeuN staining between the experimental animal and control animals. + Indicates increases in one or both inflammatory markers. ++ Indicates moderate neuronal loss in the CA1 region as observed by NeuN immunohistochemistry in combination with highly elevated Iba1 and GFAP staining. +++ Indicates severe neuronal loss in the CA1 with complete ablation of the CA1 region in some cases.