Table 1. Mean duration of each health state for patients who experienced grade 3 or 4 treatment-related toxicity.

	Mean duration of health state, days
Health state	Sunitinib	IFN- α	Mean difference, days (95% CI)
TOX	36	9	27 (18, 37)
TWiST	317	166	151 (118, 180)
REL	269	365	− 96 (−126, −56)

Abbreviations: CI=percentile confidence interval based on bootstrap samples; IFN-α=interferon-α REL=time from date of progression to death; TOX=duration between randomisation and progression spent with treatment-related grade 3 or 4 toxicity; TWiST=remaining time after TOX before progression.