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. 2012 May 10;3:102. doi: 10.3389/fimmu.2012.00102

Figure 7.

Figure 7

Proliferation of activated CD8 T cells. (A) BrdU incorporation in CD8 T cells from WT (upper left), conventional IL-2KO (upper right), Cre− (lower left), and conditional IL-2(−/−) Cre+ (lower right) mice. (B) The difference in BrdU incorporation by CD8 T cells from WT (●; n = 6), conventional IL-2KO (◼; n = 6), Cre− (▾; n = 5), and conditional IL-2(−/−) Cre+ (▴; n = 7) mice (p < 0.0001). (C) CD8 T cell proliferation monitored by the CFSE dilution from WT (upper left), conventional IL-2KO (upper right), Cre− (lower left), and conditional IL-2(−/−) Cre+ (lower right) mice. (D) The difference in CD8 T cells proliferation from WT (●; n = 6), conventional IL-2KO (◼; n = 6), Cre− (▾; n = 5), and conditional IL-2(−/−) Cre+ (▴; n = 7) mice (p < 0.0001). Anti-CD3/28-activated splenocytes were cultured for 48 h. Representative histograms were chosen from one of five to seven independent experiments. Shaded histograms represent non-activated cells. The percentages are also shown for each histogram. The results are shown as Mean ± SEM (vertical brackets). Asterisks represent the level of statistical significance.