Table 5.

Different types of CYP 450, their substrates, and inhibitors (Prior and Baker, 2003).

Types of CYP 450	Neuroleptic drugs substrates of CYP 450	Drugs inhibiting CYP 450
CYP 450- 1A2	Clozapine, haloperidol, olanzapine	Ciprofloxacin, enoxacin, fluvoxamine, cimetidine
CYP 450- 3A4	Clozapine, haloperidol, pimozide, ziprasidone, aripiprazole	Fluvoxamine, fluoxetine, ciprofloxacin, itraconazole, ketoconazole, erythromycin, clarithromycin, indinavir, ritonavir, delavirdine, efavirenz, methadone, amiodarone, cimetidine, nefazodone, grapefruit juice
CYP 450- 2D6	Clozapine, haloperidol, perphenazine, risperidone, thioridazine, aripiprazole	Fluoxetine, paroxetine, cimetidine, quinidine, ritonavir, amiodarone, clomipramine, chlorpheniramine, methadone

NB: It is noteworthy that some anti-psychotics are metabolized by several CYP 450. If one of these CYP 450 is inhibited by a drug, the metabolism of the neuroleptic will be provided by another CYP 450 whose activity is not necessarily inhibited by the same drug. This is the case, for example, of clozapine that is metabolized by the CYP 450 1A2, 3A4, and 2D6. If the activity of CYP 450 1A2 is inhibited by ciprofloxacin, enoxacin, fluvoxamine, and cimetidine, the CYP 450 3A4 and 2D6 ensure, at least in part, the metabolism of clozapine.