Figure 6.

Identification of transcripts and proteins associated with hemocytes. Representation of putative immune components present in circulating squid hemocytes. Interactions with symbiotic and/or non-symbiotic bacteria likely involve recognition by host PRRs, like PGRPs and TLR. Down stream signaling via the NF-κB pathway may modulate immune effector response. Putative members of a complement cascade as well as other immune-related genes were also expressed in circulating hemocytes. Colonization state influenced expression of a subset of these genes (_*; Figure 4), suggesting that V. fischeri can modulate the host’s cellular innate immune response. (^#), immune gene not identified in this study (Goodson et al., 2005; Rader et al., unpublished data). Localizations are inferred from protein domain predictions as well as similarity to other systems.