Figure 1.

MTM, sodium butyrate, apicidin and MS-275 protect immature cortical neurons against oxidative death by targeting overlapping pathways.

(A): MTM (300 nM), SDK (75 nM, the MTM analog that binds to DNA), sodium butyrate (5 mM), apicidin (10 nM) and MS-275 (100 nM) protect immature primary cortical neurons (E17) from oxidative stress, whereas PreB (300 nM, the MTM analog that does not bind to DNA) does not. (B and C): No increase in cell survival is detected in response to oxidative stress in cells treated with sub-protective doses of MTM (B) or its SDK analog (C) along with sub-protective doses of sodium butyrate. Statistical analysis was conducted by 1way ANOVA followed by the Dunnett post test. Significant levels compared to HCA (5 mM) treatment alone. * p < 0.05; and ** p < 0.01; and *** p < 0.0001. Cell survival experiments were repeated three times.