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SP-B inhibits sPLA2 in a concentration-dependent manner. Hydrolysis of PG in Survanta (1 mg PL/ml) by Group IB sPLA2 (0.02 U/ml) demonstrated a concentration-dependent inhibition by SP-B (0–0.01 mg/mg PL) and significant inhibition by SP-A (0–0.1 mg/mg PL). *P < 0.05 compared with control without added SP-B or SP-A.
