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SP-B inhibits PLA2G2A hydrolysis of pure PL vesicles. PL vesicles (DPPC:POPC:POPG, 40:40:20) were labeled with [H3]-PG as in Fig. 2 and incubated with either Group (Gp) IB sPLA2 (2 U/ml) or Group IIA (450 Escherichia coli U/ml) at 37°C for 2 h. Experiments were conducted in the presence and absence of 1% SP-B. Data represent the means ± SD of 4 experiments. *P < 0.05 compared with PL without SP-B.
