Fig. 10.

Constriction of human airways by Kv7 channel blocker XE991 is reversed by the calcium channel blocker verapamil. A: average time course (mean ± SE) of constriction of human airway by XE991 (10 μM, open bar) and its subsequent reversal by addition of the calcium channel blocker verapamil (10 μM, shaded bar) normalized to average control area measured during 20 min of control recording for each experiment. B: summary of effects of XE991 and verapamil on human airway luminal area (n = 4 slices containing airways of diameters ranging from 122 to 242 μm in diameter). *Significant difference from control and verapamil (P < 0.001, 1-way ANOVA).