Fig. 4.

Phenylephrine (PE)-induced concentration in the presence or absence of l-NAME in small mesenteric arteries from adult (16 wk old) Dahl S rats fed Teklad (N = 7; A) or AIN (N = 6; B) since weaning (3 wk old). At 12 wk old, weaning-diet groups were divided, with a subset of rats undergoing a diet switch, generating two additional diet groups: Teklad→AIN (N = 9; C) and AIN→Teklad (N = 5; D). l-NAME was used at 100 μM concentration to nonselectively inhibit NOS. Values are means ± SE. *P < 0.05 for logEC₅₀ in l-NAME-treated vs. untreated mesenteric artery segments. Data were analyzed by t-test.