Table 1.
Body and tissue weights and metabolic parameters in Dahl S rats at 16 wk old
| Parameter | Teklad | Teklad→AIN | AIN | AIN→Teklad |
|---|---|---|---|---|
| Tibia length, cm | 4.24 ± 0.01 (7) | 4.26 ± 0.02 (9) | 4.30 ± 0.03 (6) | 4.34 ± 0.03 (8) |
| Body weight, g/cm tibia | 100.21 ± 1.76 (7) | 98.04 ± 2.35 (9) | 96.12 ± 1.28 (6) | 97.84 ± 2.55 (8) |
| Heart, g/cm tibia | 0.37 ± 0.02 (7) | 0.34 ± 0.01 (9) | 0.31 ± 0.01 (6) | 0.32 ± 0.01 (8) |
| Kidney, g/cm tibia | 0.81 ± 0.03 (7) | 0.73 ± 0.01 (9) | 0.71 ± 0.03* (6) | 0.75 ± 0.03 (8) |
| Epididymal fat, g/cm tibia | 1.17 ± 0.05 (7) | 1.33 ± 0.07 (9) | 1.21 ± 0.09 (6) | 1.21 ± 0.12 (8) |
| Food intake, g/24 h | 25.2 ± 1.3 (8) | 21.4 ± 1.1 (9) | 20.9 ± 1.4 (7) | 25.4 ± 1.2 (5) |
| Water intake, ml/24 h | 30.1 ± 1.8 (8) | 21.8 ± 1.6 (9) | 18.4 ± 2.4 (7) | 30.1 ± 0.8 (5) |
| Na excretion, meq/24 h | 6.0 ± 0.9 (7) | 6.4 ± 0.4 (9) | 9.0 ± 1.3 (7) | 5.9 ± 0.4 (4) |
| Proteinuria, mg/24 h | 0.6 ± 0.1 (6) | 1.0 ± 0.2 (9) | 0.7 ± 0.07 (6) | 0.8 ± 0.06 (6) |
Values are means ± SE; no. of rats are in parentheses. Dahl salt-sensitive (S) rats were given Teklad or American Institutes of Nutrition (AIN) standard chow diets at weaning (3 wk old). At 12 wk, weaning-diet groups were divided, and a subset of rats underwent a diet switch, generating two additional diet groups: Teklad→AIN and AIN→Teklad.
*
P < 0.05 vs. Teklad. Data were analyzed by two-way ANOVA.