Table 5.
Maximum response (Emax) and sensitivity (logEC50) to PE or KCl in aortas from Dahl S rats at 16 wk old
| Teklad | Teklad→AIN | AIN | AIN→Teklad | |
|---|---|---|---|---|
| Emaxto [PE, 10−4.5M] or [KCl, 100 mM] | ||||
| PE, %increase in force | 137.93 ± 14.39 (6) | 152.16 ± 9.93 (9) | 127.51 ± 11.16 (6) | 116.04 ± 14.74 (6) |
| PE + l-NAME, %increase in force | 166.82 ± 18.96 (7) | 172.94 ± 8.77 (9) | 122.48 ± 11.67 (6) | 130.79 ± 11.69 (6) |
| KCl, %increase in force | 125.48 ± 9.62 (7) | 123.82 ± 3.13 (10) | 107.42 ± 9.28 (7) | 108.88 ± 14.28 (5) |
| logEC50 | ||||
| PE, M concn. | −7.3 ± 0.10 (6) | −7.3 ± 0.13 (9) | −7.3 ± 0.16 (6) | −7.2 ± 0.14 (5) |
| PE + l-NAME, M concn. | −7.6 ± 0.16 (7) | −7.6 ± 0.09 (9) | −7.5 ± 0.15 (6) | −7.3 ± 0.15 (5) |
| KCl, mM concn. | 24.6 ± 3.21 (7) | 25.0 ± 0.75 (10) | 25.1 ± 2.27 (7) | 22.9 ± 4.34 (4) |
Values are means ± SE; no. of rats are in parentheses. Dahl S rats were given Teklad or AIN standard chow diets at weaning (3 wk old). At 12 wk, weaning-diet groups were divided, and a subset of rats underwent a diet switch, generating two additional diet groups: Teklad→AIN and AIN→Teklad. l-NAME was used at 100-μM concentration to nonselectively inhibit NOS. Data were analyzed by two-way ANOVA.