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Effects of ANG II subtype receptor blockade with losartan (LOS; AT1R, gray bar) and PD123,319 (PD; AT2R, black bar) on angiotensin II-mediated contractions by denuded third generation uterine (A) and placental arteries (B) from term pregnant sheep. Note the 3-fold difference in the y-axis. Each dose includes 4–6 animals; *P ≤ 0.03 by t-test vs. ANG II alone. AT2R inhibition with PD did not enhance ANG II-mediated contractions, P > 0.1. Data are means ± SE.
